| Bioactivity | SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity[1]. | ||||||||||||
| Name | SCP1-IN-1 | ||||||||||||
| CAS | 2764615-55-4 | ||||||||||||
| Formula | C20H19F3N2O7S2 | ||||||||||||
| Molar Mass | 520.50 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519. |
SCP1-IN-1
CAS: 2764615-55-4 F: C20H19F3N2O7S2 W: 520.50
SCP1-IN-1 (compoundSH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradati
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