| Bioactivity | SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1]. |
| Target | EC50: 2.0 nM (hu-GPR109a), 96 nM (hu-GPR109b), 8.0 nM (rat-GPR109a), 6.0 nM (m-GPR109a) and 5.0 nM (dog-GPR109a) |
| Name | SCH-900271 |
| CAS | 915210-50-3 |
| Formula | C14H16N2O4 |
| Molar Mass | 276.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Anandan Palani, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. |
SCH-900271
CAS: 915210-50-3 F: C14H16N2O4 W: 276.29
SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assa
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