| Bioactivity | SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC50 of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme[1]. |
| Invitro | SC-58272 对大肠杆菌衍生的人类和白色念珠菌 (菌株 B311) Nmts (分别为 HNmt 和 CaNmt) 的 IC50 值为 56 nM 和 14100 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SC-58272 相关抗体: |
| CAS | 164931-25-3 |
| Formula | C33H52N6O4 |
| Molar Mass | 596.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jennifer K Lodge, et al. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. Microbiology (Reading). 1997 Feb:143 ( Pt 2):357-366. |