SC 51089 free base_product_DataBase

Bioactivity	SC 51089 free base is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity[1][2][3].
Invitro	SC 51089 free base (5 μM; 24 h) 减弱前列腺素 E2 (PGE2) 诱导的暴露于 t-BuOOH 的神经元细胞死亡[2]。
In Vivo	SC 51089 free base (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷[3]。 Animal Model:
Name	SC 51089 free base
CAS	146033-03-6
Formula	C22H19ClN4O3
Molar Mass	422.86
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. [2]. Saleem S, et, al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J Neurosci Res. 2007 Aug 15;85(11):2433-40. [3]. Anglada-Huguet M, et, al. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr;49(2):784-95.

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