| Bioactivity | SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1]. |
| CAS | 1321827-45-5 |
| Formula | C23H15ClN2O2 |
| Molar Mass | 386.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yongmei Feng, et al. "SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex." Cancer research 75.24 (2015): 5211-5218. |
SBI-0640726
CAS: 1321827-45-5 F: C23H15ClN2O2 W: 386.83
SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translati
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