| Bioactivity | SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2[1]. | ||||||||||||
| Invitro | SBI-0206965 (5-20 μM; 24 hours) induces apoptosis of A498 and ACHN cells during starvation[1].SBI-0206965 (5-20 μM; 24 hours) attenuates the phosphorylation of Ser108 of the AMPK β1 subunit and increases the levels of cleaved Caspase 8 and PARP, markers of apoptosis[1]. Apoptosis Analysis[1] Cell Line: | ||||||||||||
| Name | SBI-0206965 | ||||||||||||
| CAS | 1884220-36-3 | ||||||||||||
| Formula | C21H21BrN4O5 | ||||||||||||
| Molar Mass | 489.32 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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SBI-0206965
CAS: 1884220-36-3 F: C21H21BrN4O5 W: 489.32
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kina
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