| Bioactivity | SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε[1]. |
| CAS | 864431-36-7 |
| Formula | C21H23NO2 |
| Molar Mass | 321.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tal Varsano, et al. Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2. Clin Cancer Res. 2013 May 15;19(10):2710-22. |
SBI-0087702
CAS: 864431-36-7 F: C21H23NO2 W: 321.41
SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to
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