| Bioactivity | SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation[1]. |
| Invitro | SB26019（10 μM；持续 6 小时）抑制炎症标记基因的产生，例如 Ccl2、Cxcl10、Il-1β、Il-6、Nos2 和 Tnf[1]。SB26019 (1.25-10 μM; 1-12 h) 以时间和剂量依赖的方式诱导 IκB 降解[1]。SB26019（IC50 为 1.13 μM）与抗炎调节剂秋水仙碱（IC50 为 4.20 μM）相比，产生更多的 α-微管蛋白单体和更少的微管蛋白聚合物[1].SB26019 (10 μM) 诱导的 α-微管蛋白单体抑制 J774A.1 和 RAW264.7 小鼠巨噬细胞中的 p65 易位[1]。 RT-PCR[1] Cell Line: |
| In Vivo | SB26019（2-5mg/kg；i.p；每天；持续 4 天）改善体内神经炎症[1]。Pharmacokinetic (PK) analysis of SB26019[1]. Parameters |
| Name | SB26019 |
| CAS | 1233078-90-4 |
| Formula | C24H20O4 |
| Molar Mass | 372.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Junhyeong Yim, et al. Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin-p65 interaction. Exp Mol Med. 2022 Dec 12;1-10. |