| Bioactivity | SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1]. | ||||||||||||
| Target | IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK) | ||||||||||||
| Invitro | SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1]. | ||||||||||||
| Name | SB-633825 | ||||||||||||
| CAS | 956613-01-7 | ||||||||||||
| Formula | C28H25N3O3S | ||||||||||||
| Molar Mass | 483.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103. |
SB-633825
CAS: 956613-01-7 F: C28H25N3O3S W: 483.58
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, re
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