| Bioactivity | SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3]. |
| Invitro | SB-431542 (GMP) (10 μM; 10 days) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation[1].SB-431542 (GMP) (10 μM) facilitates directed differentiation into midbrain dopamine neurons (mDA)[2].SB-431542 (GMP) (3.8 μM) promotes differentiation of hPSCs to multipotent hematopoietic progenitors that arise from SOX17+ hemogenic endothelium in vitro[3]. RT-PCR[1] Cell Line: |
| Name | SB-431542 (GMP) |
| CAS | 301836-41-9 |
| Formula | C22H16N4O3 |
| Molar Mass | 384.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuchen Qi, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163. [2]. Tae Wan Kim, et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28(2):343-355.e5. [3]. Monica Nafria, et al. Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells. STAR Protoc. 2020 Oct 16;1(3):100130. |
SB-431542 (GMP)
CAS: 301836-41-9 F: C22H16N4O3 W: 384.39
SB-431542 (GMP) isSB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an a
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