| Bioactivity | SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis[1]. |
| CAS | 180083-49-2 |
| Formula | C33H34N4O3 |
| Molar Mass | 534.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Augustine‐Rauch K A, et al. Evidence for a molecular mechanism of teratogenicity of SB‐236057, a 5‐HT1B receptor inverse agonist that alters axial formation[J]. Birth Defects Research Part A: Clinical and Molecular Teratology, 2004, 70(10): 789-807. |
SB-236057
CAS: 180083-49-2 F: C33H34N4O3 W: 534.65
SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbi
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