| Bioactivity | SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H[1][2]. |
| In Vivo | SB-216641A (0.6-20 mg/kg；腹腔注射；单剂量) 在豚鼠内以剂量依赖性方式阻碍 SKF-99101H 诱导的低体温[1]。SB-216641A (559 nmol/kg；静脉注射；单剂量) 与 5-HT1B/D 受体拮抗剂 GR-127935 联用时改善了狗注射 800 nmol/kg 舒马曲坦 Sumatriptan (HY-B0121B) 后观察到的胃松弛[2]。 Animal Model: |
| Name | SB-216641A |
| CAS | 193611-67-5 |
| Formula | C28H31ClN4O4 |
| Molar Mass | 523.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. [2]. De Ponti F, et al. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G96-104. |
SB-216641A
CAS: 193611-67-5 F: C28H31ClN4O4 W: 523.02
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and
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