SARS-CoV-2-IN-34_product_DataBase

Bioactivity	SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection[1].
Invitro	SARS-CoV-2-IN-34 (0.1-100 μM; 30 min) inhibits infection by PsV of SARS variants on Huh-7 and Caco-2 cells with IC50s values ranging from 0.54 to 10.23 μM and inhibits infection of pseudotyped SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, and bat SARSr-CoV WIV1 with IC50s ranging from 1.30 to 12.02 μM[1].SARS-CoV-2-IN-34 (0.1-100 μM; 30 min) inhibits the replication of authentic SARS-CoV 2 on Caco-2 cell line with an IC50 value of 8.14 μM and inhibits authentic HCoV-OC43 and HCoV-229E infection in RD cells and Huh-7 cells with IC50s of 6.25 and 9.46 μM, respectively[1].SARS-CoV-2-IN-34 (0.1-100 μM; 2-4 h) potently inhibits cell-cell fusion mediated by S protein of SARS-CoV-2, SARS-CoV, MERS CoV, HCoV-229E and HCoV-NL63 with IC50s ranging from 1.47 to 5.44 μM[1].SARS-CoV-2-IN-34 (50 μM; 1 h) inhibits SARS-CoV-2 infection at the early stage of viral entry[1].SARS-CoV-2-IN-34 (0-2 μM) shows binding effects to S1, RBD and HR with Kd value of 67, 61 and 277 nM, respectively[1]. Cell Cytotoxicity Assay[1] Cell Line:
Name	SARS-CoV-2-IN-34
Formula	C91H119N13O16S
Molar Mass	1683.06
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB

SARS-CoV-2-IN-34

CAS: F: C91H119N13O16S W: 1683.06