| Bioactivity | SARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30 disodium exhibits antiviral activity with IC50s of 0.6 μM and 6.9 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-30 disodium induces liposomal membrane disruption with an EC50 value of 6.9 μM[1]. |
| Target | IC50: 6.9 μM (viral liposome, SARS-CoV-2) |
| Invitro | SARS-CoV-2-IN-30 (CP025) disodium inhibits SARS-CoV-2 (IC50=6.9 μM) with few cytotoxicity (Caco2 cells, CC50=106.1 μM)[1].SARS-CoV-2-IN-30 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.6 μM[1].SARS-CoV-2-IN-30 disodium suppresses varies enveloped viruses activity with IC50s of 6.1 μM (respiratory syncytial virus, RSV), 3.2 μM (influenza A virus, IAV), 7.0 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), respectively[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | SARS-CoV-2-IN-30 (CP025) disodium (150 μM, 50 μL; intranasal route; for 2-5 d) shows antiviral activity in vivo against respiratory syncytial virus (RSV) and SARS-CoV-2 in BALB/cJ mice or K18-hACE2 mice, respectively[1]. Animal Model: |
| Name | SARS-CoV-2-IN-30 disodium |
| Formula | C60H50Na2O8P2 |
| Molar Mass | 1006.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX. |
SARS-CoV-2-IN-30 disodium
CAS: F: C60H50Na2O8P2 W: 1006.96
SARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30
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