| Bioactivity | SARS-CoV-2-IN-28 is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 exhibits antiviral activity with IC50s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 induces liposomal membrane disruption with an EC50 value of 4.4 μM[1]. |
| Target | IC50: 4.4 μM (viral liposome, SARS-CoV-2) |
| Invitro | SARS-CoV-2-IN-28 (CP020) inhibits SARS-CoV-2 (IC50=1.0 μM) with few cytotoxicity (Caco2 cells, CC50=213.1 μM)[1].SARS-CoV-2-IN-28 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.4 μM[1].SARS-CoV-2-IN-28 suppresses varies enveloped viruses activity with IC50s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively[1]. Cell Viability Assay[1] Cell Line: |
| Name | SARS-CoV-2-IN-28 |
| Formula | C56H60O8P2 |
| Molar Mass | 923.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX. |