SARS-CoV-2-IN-28 disodium_product_DataBase

Bioactivity	SARS-CoV-2-IN-28 disodium is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 disodium exhibits antiviral activity with IC50s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 disodium induces liposomal membrane disruption with an EC50 value of 4.4 μM[1].
Target	IC50: 4.4 μM (viral liposome, SARS-CoV-2)
Invitro	SARS-CoV-2-IN-28 (CP020) disodium inhibits SARS-CoV-2 (IC50=1.0 μM) with few cytotoxicity (Caco2 cells, CC50=213.1 μM)[1].SARS-CoV-2-IN-28 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.4 μM[1].SARS-CoV-2-IN-28 disodium suppresses varies enveloped viruses activity with IC50s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively[1]. Cell Viability Assay[1] Cell Line:
Name	SARS-CoV-2-IN-28 disodium
Formula	C56H58Na2O8P2
Molar Mass	966.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

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