SARS-CoV-2-IN-27 disodium_product_DataBase

Bioactivity	SARS-CoV-2-IN-27 disodium is a two-armed diphosphate ester with C6 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-27 disodium exhibits antiviral activity with IC50s of 1.0 μM and 1.7 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-27 disodium induces liposomal membrane disruption with an EC50 value of 6.5 μM[1].
Target	IC50: 6.5 μM (viral liposome, SARS-CoV-2)
Invitro	SARS-CoV-2-IN-27 (CP019) disodium inhibits SARS-CoV-2 (IC50=1.7 μM) with few cytotoxicity (Caco2 cells, CC50=208 μM)[1].SARS-CoV-2-IN-27 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 1.0 μM[1].SARS-CoV-2-IN-27 disodium suppresses varies enveloped viruses activity with IC50s of 7.4 μM (respiratory syncytial virus, RSV), 112.6 μM (influenza A virus, IAV), 4.6 μM (measles virus, MeV), 1.8 μM (herpes simplex viruses, HSV-1), respectively[1]. Cell Viability Assay[1] Cell Line:
In Vivo	SARS-CoV-2-IN-27 (CP019) disodium (150 μM, 50 μL; intranasal route; for 2-5 d) shows antiviral activity in vivo against respiratory syncytial virus (RSV) and SARS-CoV-2 in BALB/cJ mice or K18-hACE2 mice, respectively[1]. Animal Model:
Name	SARS-CoV-2-IN-27 disodium
Formula	C54H54Na2O8P2
Molar Mass	938.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

PeptideDB

SARS-CoV-2-IN-27 disodium

CAS: F: C54H54Na2O8P2 W: 938.93