| Bioactivity | SARS-CoV-2 3CLpro-IN-8, an aldehyde, is a broad-spectrum cyclopropane-based inhibitor of coronavirus 3C-like proteases (3CLpro). SARS-CoV-2 3CLpro-IN-8 inhibits SARS-CoV-2, SARS-CoV-1 and MERS-CoV 3CLpro with IC50 values of 80 nM, 180 nM, 960 nM, respectively. SARS-CoV-2 3CLpro-IN-8 inhibits SARS-CoV-2 replication with an IC50 value of 12 nM[1]. |
| Invitro | SARS-CoV-2 3CLpro-IN-8 (化合物 5c) 在融合细胞中的 CC50 为 >100 μM[1]。 |
| Name | SARS-CoV-2 3CLpro-IN-8 |
| Formula | C24H32FN3O5 |
| Molar Mass | 461.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chamandi S Dampalla, et al. Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies. ACS Pharmacol Transl Sci. 2022 Dec 28;6(1):181-194. |
SARS-CoV-2 3CLpro-IN-8
CAS: F: C24H32FN3O5 W: 461.53
SARS-CoV-2 3CLpro-IN-8, an aldehyde, is a broad-spectrum cyclopropane-based inhibitor of coronavirus 3C-like proteases (
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