| Bioactivity | SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1]. | ||||||
| Target | IC50: GLP-1/GIP/GCG receptor | ||||||
| Name | SAR441255 TFA | ||||||
| Shortening | H-Aib-HGTFTSDLSKL-K(γGlu-γGlu-Palm acid)-EEQRQ-AibEFIEWLKA-dAla-GPPS-Aib-KPPPK-NH2 | ||||||
| Formula | C225H3555N57O63.xC2HF3O2 | ||||||
| Molar Mass | 4866.56 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Martin Bossart, et al. Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. Cell Metab. 2022 Jan 4;34(1):59-74.e10. |
SAR441255 TFA
CAS: F: C225H3555N57O63.xC2HF3O2 W: 4866.56 (free base)
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency wi
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