| Bioactivity | SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection[1]. |
| Target | IC50: 0.92 μM (SAP2) |
| Invitro | SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC50 value of 0.92 μM[1].SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro[1].SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1[1]. RT-PCR[1] Cell Line: |
| In Vivo | SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis[1]. Animal Model: |
| Name | SAP2-IN-1 |
| CAS | 2512847-37-7 |
| Formula | C34H29NO7 |
| Molar Mass | 563.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chenglan Li, et al. Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112515. |