| Bioactivity | SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with Ki and IC50 of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain[1]. |
| CAS | 744218-85-7 |
| Formula | C21H20N4O2S |
| Molar Mass | 392.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 AntagonistsJ. Med. Chem., Article ASAPDOI: 10.1021/jm1007825Publication Date (Web): October 8, 2010 [2]. Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. |