| Bioactivity | SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1]. | |||||||||
| Target | IC50: 28.5 nM (GPR183) | |||||||||
| Invitro | SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM[1]. Cell Viability Assay[1] Cell Line: | |||||||||
| In Vivo | SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice[1]. Animal Model: | |||||||||
| Name | SAE-14 | |||||||||
| CAS | 1241280-25-0 | |||||||||
| Formula | C19H19F3N2O2 | |||||||||
| Molar Mass | 364.36 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. |
SAE-14
CAS: 1241280-25-0 F: C19H19F3N2O2 W: 364.36
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-O
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