| Bioactivity | SAAP 148 is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC50 of 0.8-12.8 μM[1]. |
| Invitro | SAAP 148 在 PBS 和血浆中抑制 S. aureus 和 P. aeruginosa，LC99 分别为 1.6，1.6，12.8 和 12.8 μM[1]。SAAP-148 (0.4-3.2 μM，2 h) 与细菌膜相互作用并使细胞膜透化，导致细菌死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SAAP 148 相关抗体: |
| In Vivo | SAAP-148 (30 mg of 0.125-2% w/w 软膏，涂抹在皮肤上，单剂量) 可以根除皮肤上的 Methicillin (HY-121544)-耐受的 S. aureus (MRSA) 和 A. baumannii，减轻小鼠模型中的擦伤皮肤感染，且无毒性 (2000 mg/kg)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Sequence | Ac-Leu-Lys-Arg-Val-Trp-Lys-Arg-Val-Phe-Lys-Leu-Leu-Lys-Arg-Tyr-Trp-Arg-Gln-Leu-Lys-Lys-Pro-Val-Arg-NH2 |
| Shortening | Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2 |
| Formula | C157H261N49O27 |
| Molar Mass | 3267.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. de Breij A, et al., The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci Transl Med. 2018 Jan 10;10(423):eaan4044. |