SA09-Cu_product_DataBase

Bioactivity	SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].
Target	IC50: 9.6 nM (NDM-1)
Invitro	SA09-Cu (5-160 μg/mL; 24 h) 在40 μg/mL 时，使 Vero E6 和 L929 小鼠细胞的存活率高于 60%[1]。 SA09-Cu (2, 4, 8, 16 μg/mL; 24 h) 对活细胞 (E. coli-BL21-NDM-1 和 EC23) 中的 NDM-1 活性有明显的剂量依赖性的抑制作用 [1]. SA09-Cu 本身没有或只有轻微的抗菌活性 (MICs≥64 μg/mL)[1]。
Name	SA09-Cu
CAS	155641-16-0
Formula	C8H16CuN2O2S4
Molar Mass	364.03
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cheng Chen, et al. Dithiocarbamates combined with copper for revitalizing meropenem efficacy against NDM-1-producing Carbapenem-resistant Enterobacteriaceae. Bioorg Chem. 2022 Jan;118:105474.

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