S1R agonist 1 hydrochloride_product_DataBase

Bioactivity	S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
Target	Ki: 0.93 nM and 72 nM for S1R and S2R
Invitro	S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride 在 PC12 细胞中能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。S1R agonist 1 (24 h) hydrochloride 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。S1R agonist 1 (0.1-5 μM; 24 h) hydrochloride 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。S1R agonist 1 (0-10 μM; 24-72 h) hydrochloride 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。 0 --> S1R agonist 1 hydrochloride 相关抗体:
In Vivo	S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) hydrochloride 在 10 μM 下诱导 8 只斑马鱼胚胎中的 4 只死亡[1]。
Name	S1R agonist 1 hydrochloride
CAS	242487-82-7
Formula	C20H26ClNO
Molar Mass	331.88
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.

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