| Bioactivity | S07662 is a human constitutive androstane receptor (hCAR) inhibitor with an IC50 of 0.7 μM. S07662 recruits the corepressor NCoR in cell-based assays and attenuate the expression of CYP2B6 mRNA in human primary hepatocytes induced by phenytoin (HY-B0448) and CITCO (HY-103244)[1]. |
| Target | IC50: 0.7 μM (hCAR). |
| Name | S07662 |
| CAS | 883226-64-0 |
| Formula | C16H16N2O2S |
| Molar Mass | 300.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Küblbeck J, et al. New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol Pharm. 2011 Dec 5;8(6):2424-33. |