S-MGB-234_product_DataBase

Bioactivity	S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine drugs and are not internalized via the transporters used by diamidines[1].
Invitro	S-MGB-234 (compound 7) (69 hours) shows nontoxic to L6 cells with an EC50 of 20.39 μM[1].
In Vivo	S-MGB-234 (compound 7) provides total cure and no relapses in mice (cured/infected, 4/4), when treated with 2 applications of 50 mg/kg i.p.. Partial cure (1/4) is seen in mice treated with four daily applications of 10 mg/kg i.p., whilst only two applications of S-MGB-234 (compound 7) at 10 mg/kg i.p. gives no cure but prolongs survival relative to the untreated control[1].
Name	S-MGB-234
CAS	1970223-53-0
Formula	C30H32N8O4
Molar Mass	568.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Giordani F, et al. Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [published correction appears in J Med Chem. 2021 Dec 23;64(24):18236]. J Med Chem. 2019;62(6):3021-3035.

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