S-Adenosyl-L-methionine tosylate

CAS: 52248-03-0 F: C22H30N6O8S2 W: 570.64

S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine ade

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Bioactivity	S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research[1][2][3].
Invitro	S-Adenosyl-L-methionine tosylate (Ademetionine) 参与三个主要代谢途径：1) 甲基化，作为体内甲基的主要来源；2) 转硫作用，S-Adenosyl-L-methionine 形成 S-Adenosylhomocysteine (SAH)，然后转化为同型半胱氨酸 (Hcy)，同型半胱氨酸可转化为胱硫醚，再转化为半胱氨酸和硫酸盐 (SO4)，提供给其他代谢中间体；3) 氨基丙基化，因为 S-Adenosyl-L-methionine 在多胺的合成中起重要作用，最终形成和回收甲硫氨酸[2]。体外研究使用人类关节软骨细胞已显示出 S-Adenosyl-L-methionine 诱导的兔蛋白多糖合成和增殖率增加[2]。 0 --> S-Adenosyl-L-methionine tosylate 相关抗体:
In Vivo	缺乏甲硫氨酸腺苷转移酶 1a (Mat1a) 的小鼠肝脏 S-Adenosyl-L-methionine 水平降低，并发展为氧化应激、脂肪性肝炎和肝细胞癌 (HCC)。然而，如果肝脏 S-Adenosyl-L-methionine 水平长期过高，也会发生损伤和 HCC。因此，正常的肝脏 S-Adenosyl-L-methionine 水平对于维持肝脏健康和预防损伤和 HCC 是必需的[3]。
Name	S-Adenosyl-L-methionine tosylate
CAS	52248-03-0
Formula	C22H30N6O8S2
Molar Mass	570.64
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Reference	[1]. G M Bressa. et al. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.

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