| Bioactivity | S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research[1]. |
| In Vivo | S-309309 (3 mg/kg, 口服, 每天两次, 6-13 周) 抑制了DIO小鼠的食物摄入和体重增加[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2267352-04-3 |
| Formula | C23H21F2N5O5S |
| Molar Mass | 517.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miyano T, et al. The Continuous and Reversible Transformation of the Polymorphs of an MGAT2 Inhibitor (S-309309) from the Anhydrate to the Hydrate in Response to Relative Humidity. Pharmaceutics. 2024 Jul 17;16(7):949. [2]. YOSHIKI RYO, et al. 1649-P: S-309309, a Novel MGAT2 Inhibitor, Enhances Intestinal Fatty Acid Beta Oxidation and Provides Metabolic Benefits in DIO Mice. Diabetes, 2024, 73(Supplement_1). |