| Bioactivity | Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity[1]. |
| Invitro | Ru-TRZ2 (72 h) 诱导坏死性凋亡，对 HCT116 和 HT29 细胞的 IC50 值分别为 0.45 和 0.24 µM[1]。Ru-TRZ2 诱导 HT29 细胞中的线粒体去极化和细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ru-TRZ2 相关抗体: Apoptosis Analysis[1] Cell Line: |
| In Vivo | Ru-TRZ2 (5 mg/kg; i.v.; every 2 days for 10 injections) 在 HT29 异种移植小鼠中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C45H43F6N4O7P2RuS2 |
| Molar Mass | 1092.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gonçalves J, et al. Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors. Cell Death Discov. 2024 May 28;10(1):261. |