| Bioactivity | Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. |
| Target | mTOR/PI3/AKT |
| Invitro | Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。 |
| Name | Royleanone |
| CAS | 6812-87-9 |
| Formula | C20H28O3 |
| Molar Mass | 316.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. |