| Bioactivity | Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5]. | ||||||||||||
| Invitro | Rottlerin (20 μM, 2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC[2].Rottlerin (20 μM) exhibits cell proliferation in HMVEC[2]. Western Blot Analysis[2] Cell Line: | ||||||||||||
| Name | Rottlerin | ||||||||||||
| CAS | 82-08-6 | ||||||||||||
| Formula | C30H28O8 | ||||||||||||
| Molar Mass | 516.54 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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