| Bioactivity | PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death. |
| Name | Rosomidnar |
| CAS | 871597-03-4 |
| Formula | C227H291O141P23 |
| Molar Mass | 7220.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol. 2014;74(1):151-166. [2]. Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022;22(1):52-59. |
Rosomidnar
CAS: 871597-03-4 F: C227H291O141P23 W: 7220.63
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region u
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