| Bioactivity | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer[1][2][4][7]. | ||||||||||||
| Invitro | Rosiglitazone (0.1-10 μM, 72 h) results in pluripotent C3H10T1/2 stem cell differentiation to adipocytes[1].Rosiglitazone (1 μM, 24 h) activates PPARγ, which binds to NF-α1 promoter to activate gene transcription in neurons[3]. Rosiglitazone (1 μM, 24 h) protects Neuro2A cells and hippocampal neurons against oxidative stress, and up-regulates BCL-2 expression in an NF-α1-dependent manner[3].Rosiglitazone (0.01-100 μM, 15 min) inhibits TRPM3 with IC50 values of 9.5 and 4.6 μM against nifedipine- and PregS-evoked activity respectively[4].Rosiglitazone (0.5-50 μM, 7 days) inhibits ovarian cancer cell proliferation[7].Rosiglitazone (5 μM, 7 days) suppresses Olaparib (HY-10162)‑induced alterations of cellular senescence and promotes apoptosis in A2780 and SKOV3 cells[7]. Cell Proliferation Assay[7] Cell Line: | ||||||||||||
| Name | Rosiglitazone | ||||||||||||
| CAS | 122320-73-4 | ||||||||||||
| Formula | C18H19N3O3S | ||||||||||||
| Molar Mass | 357.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Rosiglitazone
CAS: 122320-73-4 F: C18H19N3O3S W: 357.43
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRP
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.