| Bioactivity | Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2]. | |||
| Invitro | Romidepsin (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner[2].Romidepsin (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells[2].Romidepsin (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression[2]. Cell Proliferation Assay[2] Cell Line: | |||
| Name | Romidepsin | |||
| CAS | 128517-07-7 | |||
| Formula | C24H36N4O6S2 | |||
| Molar Mass | 540.70 | |||
| Transport | Room temperature in continental US; may vary elsewhere. | |||
| Storage |
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
Romidepsin
CAS: 128517-07-7 F: C24H36N4O6S2 W: 540.70
Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits H
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