| Bioactivity | Ro 31-0052 is a basic radiation sensitizer, a 3'-hydroxypiperidine analog of Ro 03-8799, with improved hydrophilicity. This type of designed radiation sensitizer has better pharmacokinetic properties and has the potential to replace clinically used Misonidazole (HY-105061) and Metronidazole (HY-B0318)[1]. |
| CAS | 82381-67-7 |
| Formula | C11H18N4O4 |
| Molar Mass | 270.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dennis MF, Stratford MR, Wardman P, Watts ME. Cellular uptake of misonidazole and analogues with acidic or basic functions. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jun;47(6):629-43. [2]. Stratford M R L, et al. Pharmacokinetic studies on some novel (2-nitro-1-imidazolyl) propanolamine radiosensitizers[J]. Advanced Topics on Radiosensitizers of Hypoxic Cells, 1982: 165-169. |
Ro 31-0052
CAS: 82381-67-7 F: C11H18N4O4 W: 270.29
Ro 31-0052 is a basic radiation sensitizer, a 3'-hydroxypiperidine analog of Ro 03-8799, with improved hydrophilicity. T
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