| Bioactivity | Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM[3]. | ||||||||||||
| Invitro | Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore[2].Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death[2].Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells[3].Ro 08-2750 inhibits survival of human AML lines and patient cells[3].Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature[3]. Apoptosis Analysis[3] Cell Line: | ||||||||||||
| Name | Ro 08-2750 | ||||||||||||
| CAS | 37854-59-4 | ||||||||||||
| Formula | C13H10N4O3 | ||||||||||||
| Molar Mass | 270.24 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Ro 08-2750
CAS: 37854-59-4 F: C13H10N4O3 W: 270.24
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.