Ro 04-6790_product_DataBase

Bioactivity	Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].
Invitro	Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].
In Vivo	Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
Name	Ro 04-6790
CAS	202466-68-0
Formula	C12H16N6O2S
Molar Mass	308.36
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. [2]. Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94.

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