| Bioactivity | Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1]. |
| In Vivo | Ro 04-5595 hydrochloride (5-20 mg/kg，i.p.) 抑制 MA 诱导的小鼠中运动刺激[2]。Ro 04-5595 hydrochloride (10mg/kg，i.p.，持续 6 天) 降低可卡因给药大鼠的 AMPA 与 NMDA 比率[3]。 Animal Model: |
| Name | Ro 04-5595 hydrochloride |
| CAS | 64047-73-0 |
| Formula | C19H23Cl2NO2 |
| Molar Mass | 368.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55. [2]. Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. [3]. deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405. |