| Bioactivity | Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. Ritlecitinib (malonate) can be used for the research of inflammatory and autoimmune diseases[1]. |
| Target | IC50: 33.1 nM (JAK3) |
| Name | Ritlecitinib (malonate) |
| CAS | 2140301-97-7 |
| Formula | C18H23N5O5 |
| Molar Mass | 389.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. |
Ritlecitinib (malonate)
CAS: 2140301-97-7 F: C18H23N5O5 W: 389.41
Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. Ritlecitin
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