| Bioactivity | Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase. | ||||||||||||
| Invitro | Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase. | ||||||||||||
| Name | Rifabutin | ||||||||||||
| CAS | 72559-06-9 | ||||||||||||
| Formula | C46H62N4O11 | ||||||||||||
| Molar Mass | 847.00 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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Rifabutin
CAS: 72559-06-9 F: C46H62N4O11 W: 847.00
Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibi
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