| Bioactivity | Ribavirin-15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。用 5、10 和 20 μM Ribavirin (ICN-1229) 处理 LPS 刺激的小胶质细胞可诱导 NO2 水平降低 43% (p 0 --> Ribavirin-15N, d2 相关抗体: |
| In Vivo | ALT、AST 活性和胆红素水平通过 JAT 联合干扰素和 Ribavirin (ICN-1229) 给药显著降低 (p<0.01)。JAT、干扰素或 Ribavirin 单独与 CCl4 一起使用时，肝脏似乎对 CCl4 表现出一定的肝脏保护作用，这可以通过正常肝索的存在、无坏死和较少脂肪来证明浸润。用 JAT、聚乙二醇干扰素和 Ribavirin (ICN-1229) 单独或联合处理的组显示 TGF-β 和 Bax 的表达减少。在干扰素、Ribavirin (ICN-1229) 和JAT三联处理组中，p53的表达水平明显降低[2]。 Ribavirin (ICN-1229) 胶囊 (400 毫克 Ribavirin) 处理的 Wistar 大鼠在血清和肝脏水平显示激活素 A 显著减少和卵泡抑素显著增加。只有当 Ribavirin 与 IFN-α 或 Peg-IFN-α 联合使用时，Ribavirin (ICN-1229) 才具有很强的抗病毒活性[3]。 Ribavirin (40 mg/kg，po) 显著提高 CM-10-18 在小鼠体内的抗病毒功效。Ribavirin (ICN-1229) 可抑制培养细胞中的 DENV 病毒感染，但单药处理对降低病毒血症无效[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C8H10D2N315NO5 |
| Molar Mass | 247.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Savic D, et al. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacol Immunotoxicol. 2014 Dec;36(6):433-41 [3]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23. [4]. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265 [5]. Chang J, et al. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res. 2011 Jan;89(1):26-34 [6]. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85. |
Ribavirin-15N, d2
CAS: F: C8H10D2N315NO5 W: 247.21
Ribavirin-15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against
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This product is for research use only, not for human use. We do not sell to patients.