Ribavirin (GMP)_product_DataBase

Bioactivity	Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
Invitro	用 5、10 和 20 μM Ribavirin GMP (ICN-1229) 处理 LPS 刺激的小胶质细胞可诱导 NO2 水平降低 43% (p 0 --> Ribavirin (GMP) 相关抗体: Real Time qPCR[7] Cell Line:
In Vivo	ALT、AST 活性和胆红素水平通过 JAT 联合干扰素和 Ribavirin GMP (ICN-1229) 给药显著降低 (p<0.01)。JAT、干扰素或 Ribavirin GMP 单独与 CCl4 一起使用时，肝脏似乎对 CCl4 表现出一定的肝脏保护作用，这可以通过正常肝索的存在、无坏死和较少脂肪来证明浸润。用 JAT、聚乙二醇干扰素和 Ribavirin GMP (ICN-1229) 单独或联合处理的组显示 TGF-β 和 Bax 的表达减少。在干扰素、Ribavirin GMP (ICN-1229) 和JAT三联处理组中，p53的表达水平明显降低[1]。 Ribavirin GMP (ICN-1229) 胶囊 (400 毫克 Ribavirin GMP) 处理的 Wistar 大鼠在血清和肝脏水平显示激活素 A 显著减少和卵泡抑素显著增加。只有当 Ribavirin GMP 与 IFN-α 或 Peg-IFN-α 联合使用时，Ribavirin GMP (ICN-1229) 才具有很强的抗病毒活性[2]。 Ribavirin GMP (40 mg/kg，po) 显著提高 CM-10-18 在小鼠体内的抗病毒功效。Ribavirin GMP (ICN-1229) 可抑制培养细胞中的 DENV 病毒感染，但单药处理对降低病毒血症无效[4]。
Name	Ribavirin (GMP)
CAS	36791-04-5
Formula	C8H12N4O5
Molar Mass	244.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23. [2]. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85. [3]. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265 [4]. Savic D, et al. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacol Immunotoxicol. 2014 Dec;36(6):433-41 [5]. Chang J, et al. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res. 2011 Jan;89(1):26-34 [6]. Sa-Ngiamsuntorn K, et al. A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host. Virol J. 2016 Apr 5;13:59. [7]. Kim JA, Seong RK, Kumar M, Shin OS. Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models. Viruses. 2018 Feb 9;10(2):72.

PeptideDB

Ribavirin (GMP)

CAS: 36791-04-5 F: C8H12N4O5 W: 244.20