| Bioactivity | Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis[1]. | ||||||||||||
| Target | EC50: 19.5 μM (ACE2) | ||||||||||||
| Invitro | Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively[1].ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology[1]. | ||||||||||||
| Name | Resorcinolnaphthalein | ||||||||||||
| CAS | 41307-63-5 | ||||||||||||
| Formula | C24H14O5 | ||||||||||||
| Molar Mass | 382.36 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hernández Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7. |
Resorcinolnaphthalein
CAS: 41307-63-5 F: C24H14O5 W: 382.36
Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an
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