| Bioactivity | Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2]. |
| Invitro | RvD3 (RvD3; 10 nM) significantly inhibits tumor necrosis factor-α–induced NF-κB activation in A549 epithelial cells[2]. |
| In Vivo | Resolvin D3 (RvD3; 100 ng/100 µl; IP; daily for 6 days) alleviates arthritis progression, reduces edema and limits leukocyte numbers in murine K/BxN-serum induced arthritis[1]. Animal Model: |
| Name | Resolvin D3 |
| CAS | 916888-47-6 |
| Formula | C22H32O5 |
| Molar Mass | 376.49 |
| Appearance | Liquid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Solution, -20°C, 2 years |
| Reference | [1]. Hildur H Arnardottir, et al. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 Sep 15;197(6):2362-8. [2]. Jennifer K Colby, et al. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 Jul;186(7):1801-1813. |
Resolvin D3
CAS: 916888-47-6 F: C22H32O5 W: 376.49
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduce
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