| Bioactivity | Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4]. |
| Invitro | Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1].Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1].Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1].Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3]. |
| Name | Resistomycin |
| CAS | 20004-62-0 |
| Formula | C22H16O6 |
| Molar Mass | 376.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |