Renin inhibitor-1

CAS: 1093082-54-2 F: C22H30N4O4 W: 414.50

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].
Target	IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)
In Vivo	Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].
Name	Renin inhibitor-1
CAS	1093082-54-2
Formula	C22H30N4O4
Molar Mass	414.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.

Edoxaban impurity 4