| Bioactivity | Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood[1]. Remibrutinib has the potential for Chronic urticaria (CU) treatment[2]. | ||||||||||||
| Target | IC50: 1 nM (BTK) | ||||||||||||
| Invitro | In a biochemical enzyme assay,Remibrutinib (example 6) inhibits Btk enzymatic activity with an IC50 value of 1 nM[1].In vitro B cell activation assay, Remibrutinib inhibits Btk enzymatic activity in blood with an IC50 value of 0.023 μM, the whole blood is collected from the abdominal aorta of anaesthetized adult male Lewis rats[1]. | ||||||||||||
| Name | Remibrutinib | ||||||||||||
| CAS | 1787294-07-8 | ||||||||||||
| Formula | C27H27F2N5O3 | ||||||||||||
| Molar Mass | 507.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1. [2]. Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23. |
Remibrutinib
CAS: 1787294-07-8 F: C27H27F2N5O3 W: 507.53
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibruti
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.