Remeglurant

CAS: 1309783-00-3 F: C17H15BrN4O W: 371.23

Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50

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Bioactivity	Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD)[1][2].
CAS	1309783-00-3
Formula	C17H15BrN4O
Molar Mass	371.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pamela R Westmark, et al. Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056. Neurobiol Dis. 2018 Nov:119:190-198. [2]. Philippe Huot, et al. Targeting metabotropic glutamate receptors for the treatment of Parkinson's disease. Neurodegener Dis Manag. 2023 Aug;13(4):203-206.