| Bioactivity | Frangulin B (Compd 11g), a potent anticancer agent, is a potential pan RecQ helicase inhibitor[1]. Frangulin B (Compd 11g) induces apoptosis in both HCT-116 and MDA-MB-231 cell lines, but also causes an G2/M phase cell cycle arrest in HCT-116 cells[1]. |
| Name | RecQ helicase-IN-1 |
| Formula | C25H21N3O3 |
| Molar Mass | 411.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hanan S Haggag, et al. Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases. Bioorg Chem. 2024 Jan 4:144:107086. |